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Cellosaurus CO (CVCL_J653)

Cell line name CO
Synonyms COLE; Cole; Co
Accession CVCL_J653
Resource Identification Initiative To cite this cell line use: CO (RRID:CVCL_J653)
Comments Problematic cell line: Contaminated. Shown to be a CCRF-CEM derivative (PubMed=12581897; PubMed=12592342; PubMed=20143388). Originally thought to originate from the lymph node biopsy of a patient with Hodgkin lymphoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00186.
Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for FLT3 p.Ala627Thr (c.1879G>A) (from parent cell line).
Heterozygous for KRAS p.Gly12Asp (c.35G>A) (from parent cell line).
Heterozygous for TP53 p.Arg175His (c.524G>A) and p.Arg248Gln (c.743G>A) (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0207 (CCRF-CEM)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx
Publications

PubMed=4018743; DOI=10.1002/hon.2900030205
Jones D.B., Scott C.S., Wright D.H., Stein H., Beverley P.C.L., Payne S.V., Crawford D.H.
Phenotypic analysis of an established cell line derived from a patient with Hodgkin's disease (HD).
Hematol. Oncol. 3:133-145(1985)

PubMed=2602651; DOI=10.1007/978-3-642-83781-4_6
Jones D.B., Furley A.J.W., Gerdes J., Greaves M.F., Stein H., Wright D.H.
Phenotypic and genotypic analysis of two cell lines derived from Hodgkin's disease tissue biopsies.
Recent Results Cancer Res. 117:62-66(1989)

PubMed=2690233; DOI=10.1007/978-3-642-83781-4_5
Schaadt M., Burrichter H., Pfreundschuh M., Schell-Frederick E., Tesch H., Fonatsch C., Stein H., Diehl V.
Biology of Hodgkin cell lines.
Recent Results Cancer Res. 117:53-61(1989)

PubMed=8558920
Dirks W.G., Zaborski M., Jager K., Challier C., Shiota M., Quentmeier H., Drexler H.G.
The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.
Leukemia 10:142-149(1996)

PubMed=12581897; DOI=10.1016/S0165-4608(02)00656-8
Berglund M., Flordal E., Gullander J., Lui W.-O., Larsson C., Lagercrantz S., Enblad G.
Molecular cytogenetic characterization of four commonly used cell lines derived from Hodgkin lymphoma.
Cancer Genet. Cytogenet. 141:43-48(2003)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Biological sample resources BioSample; SAMN03151618
Other Wikidata; Q54813920
Polymorphism and mutation databases Cosmic; 1086354
Cosmic; 1486583