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Cellosaurus p53R (CVCL_J916)

[Text version]

Cell line name p53R
Accession CVCL_J916
Resource Identification Initiative To cite this cell line use: p53R (RRID:CVCL_J916)
Comments Problematic cell line: Misidentified. Originally thought to derive from Hs 766T but was later (erratum) shown to be derived from RKO (PubMed=12082016).
Sequence variations Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0504 (RKO)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO8,10
D5S81811,13
D7S8208,10
D13S3178,11
D16S53912,13
TH016,10
TPOX11
vWA16,22

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Publications

PubMed=12082016; DOI=10.1093/carcin/23.6.949
Sohn T.A., Bansal R., Su G.H., Murphy K.M., Kern S.E.
High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated Tp53-responsive luciferase reporter.
Carcinogenesis 23:949-957(2002)

Cross-references
Cell line collections ATCC; CRL-2781 - Discontinued
ATCC; JHU-56 - Discontinued
Biological sample resources BioSample; SAMN03471788
Other Wikidata; Q54937309
Entry history
Entry creation11-Feb-2013
Last entry update20-May-2021
Version number17