ID   p53R
AC   CVCL_J916
DR   ATCC; CRL-2781
DR   ATCC; JHU-56
DR   BioSample; SAMN03471788
DR   cancercelllines; CVCL_J916
DR   Wikidata; Q54937309
RX   PubMed=12082016;
CC   Problematic cell line: Misidentified. Originally thought to derive from Hs 766T but was later (erratum) shown to be derived from RKO (PubMed=12082016).
CC   Sequence variation: Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
CC   Discontinued: ATCC; CRL-2781; true.
CC   Discontinued: ATCC; JHU-56; true.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
ST   Source(s): ATCC
ST   Amelogenin: X
ST   CSF1PO: 8,10
ST   D13S317: 8,11
ST   D16S539: 12,13
ST   D5S818: 11,13
ST   D7S820: 8,10
ST   TH01: 6,10
ST   TPOX: 11
ST   vWA: 16,22
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0504 ! RKO
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 05-10-23; Version: 19
//
RX   PubMed=12082016; DOI=10.1093/carcin/23.6.949;
RA   Sohn T.A., Bansal R., Su G.H., Murphy K.M., Kern S.E.;
RT   "High-throughput measurement of the Tp53 response to anticancer drugs
RT   and random compounds using a stably integrated Tp53-responsive
RT   luciferase reporter.";
RL   Carcinogenesis 23:949-957(2002).
//