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Cellosaurus HEp-3 (CVCL_JB77)

[Text version]

Cell line name HEp-3
Synonyms H.Ep. #3; H.Ep. No. 3; HEp3; Human Epidermoid carcinoma #3
Accession CVCL_JB77
Resource Identification Initiative To cite this cell line use: HEp-3 (RRID:CVCL_JB77)
Comments Population: African American.
Disease Buccal mucosa squamous cell carcinoma (NCIt: C4040)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Derived from metastatic site: Cervical lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling 62Y
Category Cancer cell line

Toolan H.W.
Transplantable human neoplasms maintained in cortisone-treated laboratory animals: H.S. No. 1; H.Ep. No. 1; H.Ep. No. 2; H.Ep. No. 3 and H.Emb.Rh. No. 1.
Cancer Res. 14:660-666(1954)

Moore A.E., Sabachewsky L., Toolan H.W.
Culture characteristics of four permanent lines of human cancer cells.
Cancer Res. 15:598-602(1955)

PubMed=5835037; DOI=10.1093/jnci/35.3.435
Miles C.P., O'Neill F.
Chromosomes of some heterotransplanted human tumors. II. H.Ep. no. 1, H.Ep. no. 3, and H.Ep. no. 5.
J. Natl. Cancer Inst. 35:435-458(1965)

Biedler J.L.
Chromosome abnormalities in human tumor cells in culture.
(In) Human tumor cells in vitro; Fogh J. (eds.); pp.359-394; Springer; New York (1975)

PubMed=3119604; DOI=10.1002/jcp.1041330212
Ossowski L., Russo H., Gartner M., Wilson E.L.
Growth of a human carcinoma (HEp3) in nude mice: rapid and efficient metastasis.
J. Cell. Physiol. 133:288-296(1987)

Testa J.E.
Loss of the metastatic phenotype by a human epidermoid carcinoma cell line, HEp-3, is accompanied by increased expression of tissue inhibitor of metalloproteinase 2.
Cancer Res. 52:5597-5603(1992)

PubMed=9650562; DOI=10.1002/(SICI)1097-0215(19980717)77:2<257::AID-IJC15>3.0.CO;2-8
Lyu M.-A., Choi Y.-K., Park B.-N., Kim B.-J., Park I.-K., Hyun B.-H., Kook Y.-H.
Over-expression of urokinase receptor in human epidermoid-carcinoma cell line (HEp3) increases tumorigenicity on chorio-allantoic membrane and in severe-combined-immunodeficient mice.
Int. J. Cancer 77:257-263(1998)

Anatomy/cell type resources BTO; BTO:0005139
Encyclopedic resources Wikidata; Q54882764
Entry history
Entry creation15-May-2017
Last entry update29-Oct-2020
Version number6