| Cell line name |
POLK CD MSH- |
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| Synonyms |
Nalm-6-MSH-/TK+/-/POLK D198A,D199A |
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| Accession |
CVCL_JH02 |
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| Resource Identification Initiative |
To cite this cell line use: POLK CD MSH- (RRID:CVCL_JH02) |
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| Comments |
Population: Caucasian.
Knockout cell: Method=Homologous recombination; HGNC; 11830; TK1 (Note=1 of 2 alleles).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. |
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| Sequence variations |
- Gene fusion; HGNC; 50800; DUX4 + HGNC; 5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line).
- Mutation; HGNC; 3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9183; POLK; Simple_edited; p.Asp198Ala; Zygosity=Unspecified; Note=Loss of activity. By homologous recombination (PubMed=24461735).
- Mutation; HGNC; 9183; POLK; Simple_edited; p.Asp199Ala; Zygosity=Unspecified; Note=Loss of activity. By homologous recombination (PubMed=24461735).
- Mutation; HGNC; 9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).
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| Disease |
Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_UD96 (Nalm-6-TK+/-) |
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| Sex of cell |
Male |
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| Age at sampling |
19Y |
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| Category |
Cancer cell line |
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| STR profile |
Source(s): JCRB
Markers:
Run an STR similarity search on this cell line |
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| Publications | PubMed=24461735; DOI=10.1016/j.dnarep.2013.12.008
Sassa A., Suzuki T., Kanemaru Y., Niimi N., Fujimoto H., Katafuchi A., Gruz P., Yasui M., Gupta R.C., Johnson F., Ohta T., Honma M., Adachi N., Nohmi T.
In vivo evidence that phenylalanine 171 acts as a molecular brake for translesion DNA synthesis across benzo[a]pyrene DNA adducts by human DNA polymerase kappa.
DNA Repair 15:21-28(2014) |
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| Cross-references |
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| Cell line collections (Providers) |
JCRB; JCRB1523
|
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| Cell line databases/resources |
cancercelllines; CVCL_JH02
|
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| Encyclopedic resources |
Wikidata; Q54947711
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| Entry history |
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| Entry creation | 15-May-2017 |
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| Last entry update | 30-Jan-2024 |
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| Version number | 14 |
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