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Cellosaurus S462.TY (CVCL_JK02)

[Text version]
Cell line name S462.TY
Synonyms S462-TY; S462TY
Accession CVCL_JK02
Resource Identification Initiative To cite this cell line use: S462.TY (RRID:CVCL_JK02)
Comments Characteristics: Was created by passage of S462 as xenografts.
Derived from site: In situ; Thigh; UBERON=UBERON_0000376.
Sequence variations
  • Gene deletion; HGNC; 7765; NF1; Zygosity=Heterozygous (from parent cell line).
  • Gene deletion; HGNC; 11998; TP53; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7765; NF1; Simple; p.Tyr2285Ter (c.6792C>A); ClinVar=VCV000185082; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg110Pro (c.329G>C); ClinVar=VCV000233627; Zygosity=Heterozygous (from parent cell line).
Disease Malignant peripheral nerve sheath tumor (NCIt: C3798)
Neurofibromatosis type 1 (NCIt: C3273)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Neurofibromatosis type 1 (ORDO: Orphanet_636)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1Y70 (S462)
Sex of cell Female
Age at sampling 19Y
Category Cancer cell line
Publications

PubMed=18281493; DOI=10.1158/0008-5472.CAN-07-2734
Mahller Y.Y., Vaikunth S.S., Ripberger M.C., Baird W.H., Saeki Y., Cancelas J.A., Crombleholme T.M., Cripe T.P.
Tissue inhibitor of metalloproteinase-3 via oncolytic herpesvirus inhibits tumor growth and vascular progenitors.
Cancer Res. 68:1170-1179(2008)

PubMed=28469964
Guo J.-M., Grovola M.R., Xie H., Coggins G.E., Duggan P., Hasan R., Huang J.-L., Lin D.W., Song C., Witek G.M., Berritt S., Schultz D.C., Field J.
Comprehensive pharmacological profiling of neurofibromatosis cell lines.
Am. J. Cancer Res. 7:923-934(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_JK02
Encyclopedic resources Wikidata; Q54951929
Entry history
Entry creation15-May-2017
Last entry update05-Oct-2023
Version number11