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Cellosaurus BEL-A (CVCL_JM04)

[Text version]
Cell line name BEL-A
Synonyms BEL-A2; Bristol Erythroid Line-Adult
Accession CVCL_JM04
Resource Identification Initiative To cite this cell line use: BEL-A (RRID:CVCL_JM04)
Comments Characteristics: Differentiates efficiently into mature, functional reticulocytes.
Doubling time: 20 hours (PubMed=28290447); 18.7 +- 2.0 hours (PubMed=31753923).
Transfected with: UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Transfected with: UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: Mononuclear cell; CL=CL_0000842.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C0X7 (BEL-A2 clone 79)
Sex of cell Sex unspecified
Age at sampling Adult
Category Transformed cell line
Web pages http://www.sciencealert.com/immortal-stem-cells-let-scientists-create-an-unlimited-supply-of-artificial-blood
Publications

PubMed=28290447; DOI=10.1038/ncomms14750
Trakarnsanga K., Griffiths R.E., Wilson M.C., Blair A., Satchwell T.J., Meinders M., Cogan N., Kupzig S., Kurita R., Nakamura Y., Toye A.M., Anstee D.J., Frayne J.
An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells.
Nat. Commun. 8:14750.1-14750.7(2017)

CLPUB00710
Hawksworth J.S.
CRISPR-Cas9 gene editing in an immortalized erythroid cell line for production of engineered red blood cells.
Thesis PhD (2019), University of Bristol, United Kingdom

PubMed=31753923; DOI=10.3324/haematol.2019.229211
Daniels D.E., Downes D.J., Ferrer-Vicens I., Ferguson D.C.J., Singleton B.K., Wilson M.C., Trakarnsanga K., Kurita R., Nakamura Y., Anstee D.J., Frayne J.
Comparing the two leading erythroid lines BEL-A and HUDEP-2.
Haematologica 105:E389-E394(2020)

Cross-references
Encyclopedic resources Wikidata; Q54795987
Entry history
Entry creation15-May-2017
Last entry update05-Oct-2023
Version number12