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Cellosaurus DKFZ-BT66 (CVCL_JX58)

[Text version]
Cell line name DKFZ-BT66
Accession CVCL_JX58
Resource Identification Initiative To cite this cell line use: DKFZ-BT66 (RRID:CVCL_JX58)
Comments Characteristics: Transduced with a doxycycline-inducible system coding for SV40 large T antigen and RFP (PubMed=28002790).
Senescence: Withdrawal of doxycyclin leads to senescence (PubMed=28002790).
Doubling time: 45 hours (PubMed=28002790).
Transfected with: UniProtKB; Q9U6Y8; Discosoma sp. red fluorescent protein drFP583 (DsRed, RFP).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Brain, cerebellum; UBERON=UBERON_0002037.
Sequence variations
  • Gene fusion; HGNC; 1097; BRAF + HGNC; 22219; KIAA1549; Name(s)=KIAA1549-BRAF; Note=KIAA1549 exon 16 fused to BRAF exon 9 (PubMed=28002790).
Disease Pilocytic astrocytoma (NCIt: C4047)
Pilocytic astrocytoma (ORDO: Orphanet_251612)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 2Y
Category Cancer cell line
Publications

PubMed=28002790; DOI=10.18632/oncotarget.14004
Selt F., Hohloch J., Hielscher T., Sahm F., Capper D., Korshunov A., Usta D., Brabetz S., Ridinger J., Ecker J., Oehme I., Gronych J., Marquardt V., Pauck D., Bachli H., Stiles C.D., von Deimling A., Remke M., Schuhmann M.U., Pfister S.M., Brummer T., Jones D.T.W., Witt O., Milde T.
Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing.
Oncotarget 8:11460-11479(2017)

PubMed=35977048; DOI=10.1093/neuonc/noac199
Selt F., Sigaud R., Valinciute G., Sievers P., Zaman J., Alco C., Schmid S., Peterziel H., Tsai J.W., Guiho R., Martinez-Barbera J.P., Pusch S., Deng J., Zhai Y.-F., van Tilburg C.M., Schuhmann M.U., El Damaty A., Bandopadhayay P., Herold-Mende C., von Deimling A., Pfister S.M., Montero J., Capper D., Oehme I., Sahm F., Jones D.T.W., Witt O., Milde T.
BH3 mimetics targeting BCL-XL impact the senescent compartment of pilocytic astrocytoma.
Neuro-oncol. 25:735-747(2023)

Cross-references
Encyclopedic resources Wikidata; Q54831117
Entry history
Entry creation22-Aug-2017
Last entry update05-Oct-2023
Version number8