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Cellosaurus MCF7T2 (CVCL_JX65)

[Text version]

Cell line name MCF7T2
Accession CVCL_JX65
Resource Identification Initiative To cite this cell line use: MCF7T2 (RRID:CVCL_JX65)
Comments Part of: MD Anderson Cell Lines Project.
Characteristics: Transfected with reverse tetracycline-controlled transactivator (rtTA), a fusion between a mutated version of E.coli TetR and the activating domain of HSV-1 VP16.
Transfected with: HGNC; 1589; CCNE1 (M-1--N-64 del, M-65 called 'truncation 2').
Transfected with: UniProtKB; P04483; E.coli Tn10 tetR.
Transfected with: UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (with del 1-360).
Omics: Protein expression by reverse-phase protein arrays.
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_V332 (MCF7 Tet-On)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Web pages http://tcpaportal.org/mclp/

PubMed=21695458; DOI=10.1007/s10549-011-1638-4
Nanos-Webb A., Jabbour N.A., Multani A.S., Wingate H., Oumata N., Galons H., Joseph B., Meijer L., Hunt K.K., Keyomarsi K.
Targeting low molecular weight cyclin E (LMW-E) in breast cancer.
Breast Cancer Res. Treat. 132:575-588(2012)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Other Wikidata; Q54904477
Entry history
Entry creation22-Aug-2017
Last entry updated02-Jul-2020
Version number5