ID   MCF7T2
AC   CVCL_JX65
DR   cancercelllines; CVCL_JX65
DR   Wikidata; Q54904477
RX   PubMed=21695458;
RX   PubMed=28196595;
WW   https://tcpaportal.org/mclp/
CC   Part of: MD Anderson Cell Lines Project.
CC   Population: Caucasian.
CC   Characteristics: Transfected with reverse tetracycline-controlled transactivator (rtTA), a fusion between a mutated version of E.coli TetR and the activating domain of HSV-1 VP16.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: HGNC; 1589; CCNE1 (M-1--N-64 del, M-65 called 'truncation 2').
CC   Transfected with: UniProtKB; P04483; Escherichia coli Tn10 tetR.
CC   Transfected with: UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (with p.Met1_Arg360del).
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_V332 ! MCF7 Tet-On
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 22-08-17; Last updated: 05-10-23; Version: 12
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RX   PubMed=21695458; DOI=10.1007/s10549-011-1638-4;
RA   Nanos-Webb A., Jabbour N.A., Multani A.S., Wingate H., Oumata N.,
RA   Galons H., Joseph B., Meijer L., Hunt K.K., Keyomarsi K.;
RT   "Targeting low molecular weight cyclin E (LMW-E) in breast cancer.";
RL   Breast Cancer Res. Treat. 132:575-588(2012).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//