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Cellosaurus Kasumi-1 R48 (CVCL_JY44)

[Text version]
Cell line name Kasumi-1 R48
Synonyms R48
Accession CVCL_JY44
Resource Identification Initiative To cite this cell line use: Kasumi-1 R48 (RRID:CVCL_JY44)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:49375; Dasatinib (BMS-354825).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 10471; RUNX1 + HGNC; 1535; RUNX1T1; Name(s)=RUNX1-RUNX1T1, AML1-ETO (from parent cell line).
  • Mutation; HGNC; 6342; KIT; Simple; p.Asn822Lys (c.2466T>A) (N818K); ClinVar=VCV000375931; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 9811; RAD21; Simple; p.Lys330Profs*6 (c.987insCCGG); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Childhood acute myeloid leukemia with maturation (NCIt: C9381)
Acute myeloblastic leukemia with maturation (ORDO: Orphanet_98834)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0589 (Kasumi-1)
Children:
CVCL_JY45 (Kasumi-1 PR48)
Sex of cell Male
Age at sampling 7Y
Category Cancer cell line
Publications

PubMed=24211243; DOI=10.1016/j.exphem.2013.10.006
Herrmann M.D., Lennerz J.K., Bullinger L., Bartholomae S., Holzmann K., Westhoff M.-A., Corbacioglu S., Debatin K.-M.
Transitory dasatinib-resistant states in KIT(mut) t(8;21) acute myeloid leukemia cells correlate with altered KIT expression.
Exp. Hematol. 42:90-100(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_JY44
Encyclopedic resources Wikidata; Q54899514
Gene expression databases GEO; GSM955192
GEO; GSM955193
GEO; GSM955194
Entry history
Entry creation22-Aug-2017
Last entry update05-Oct-2023
Version number13