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Cellosaurus EU-2 (CVCL_K034)

Cell line name EU-2
Synonyms 207; Line 207; Emory University-2
Accession CVCL_K034
Secondary accession CVCL_8860
Resource Identification Initiative To cite this cell line use: EU-2 (RRID:CVCL_K034)
Comments Derived from sampling site: Bone marrow.
Sequence variations TP53 p.Arg248Gln (c.743G>A) (PubMed=7888679).
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 10Y
Category Cancer cell line

Findley H.W. Jr., Cooper M.D., Kim T.H., Alvarado C., Ragab A.H.
Two new acute lymphoblastic leukemia cell lines with early B-cell phenotypes.
Blood 60:1305-1309(1982)

Zhou M., Gu L., James C.D., He J., Yeager A.M., Smith S.D., Findley H.W.
Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines established from children with acute lymphoblastic leukemia.
Leukemia 9:1159-1161(1995)

Zhou M., Yeager A.M., Smith S.D., Findley H.W.
Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene.
Blood 85:1608-1614(1995)

Findley H.W., Gu L., Yeager A.M., Zhou M.
Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia.
Blood 89:2986-2993(1997)

PubMed=9823951; DOI=10.1038/sj.leu.2401198
Zhou M., Gu L., Yeager A.M., Findley H.W.
Sensitivity to Fas-mediated apoptosis in pediatric acute lymphoblastic leukemia is associated with a mutant p53 phenotype and absence of Bcl-2 expression.
Leukemia 12:1756-1763(1998)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

Other Wikidata; Q54832863