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Cellosaurus EU-2 (CVCL_K034)

Cell line name EU-2
Synonyms 207; Line 207; Emory University-2
Accession CVCL_K034
Secondary accession CVCL_8860
Resource Identification Initiative To cite this cell line use: EU-2 (RRID:CVCL_K034)
Comments Derived from sampling site: Bone marrow.
Sequence variations TP53 p.Arg248Gln (c.743G>A) (PubMed=7888679).
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 10Y
Category Cancer cell line
Publications

PubMed=6982733
Findley H.W. Jr., Cooper M.D., Kim T.H., Alvarado C., Ragab A.H.
Two new acute lymphoblastic leukemia cell lines with early B-cell phenotypes.
Blood 60:1305-1309(1982)

PubMed=7630190
Zhou M., Gu L., James C.D., He J., Yeager A.M., Smith S.D., Findley H.W.
Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines established from children with acute lymphoblastic leukemia.
Leukemia 9:1159-1161(1995)

PubMed=7888679
Zhou M., Yeager A.M., Smith S.D., Findley H.W.
Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene.
Blood 85:1608-1614(1995)

PubMed=9108419
Findley H.W., Gu L., Yeager A.M., Zhou M.
Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia.
Blood 89:2986-2993(1997)

PubMed=9823951; DOI=10.1038/sj.leu.2401198
Zhou M., Gu L., Yeager A.M., Findley H.W.
Sensitivity to Fas-mediated apoptosis in pediatric acute lymphoblastic leukemia is associated with a mutant p53 phenotype and absence of Bcl-2 expression.
Leukemia 12:1756-1763(1998)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

Cross-references
Other Wikidata; Q54832863