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Cellosaurus T47D-KBluc (CVCL_K229)

[Text version]

Cell line name T47D-KBluc
Synonyms T47D-KBLUC; T47D Kbluc; T47D_KBluc; T47DKBluc; T47DKBLUC
Accession CVCL_K229
Resource Identification Initiative To cite this cell line use: T47D-KBluc (RRID:CVCL_K229)
Comments Part of: GrayJW breast cancer cell line panel.
Doubling time: 70.61 hours (https://www.synapse.org/#!Synapse:syn2347014).
Transfected with: UniProtKB; P08659; Firefly luciferase.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Sequence variations Heterozygous for PIK3CA p.His1047Arg (c.3140A>G) (ClinVar=VCV000013652) (from parent cell line).
Homozygous for TP53 p.Leu194Phe (c.580C>T) (from parent cell line).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*33:01,33:01
HLA-BB*14:02,14:02
HLA-CC*08:02,08:02
Class II
HLA-DQDQA1*01:02,01:02
DQB1*05:01,05:01
HLA-DRDRB1*01:02,01:02
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0553 (T-47D)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO11,13
D5S81812
D7S82011
D13S31712
D16S53910
TH016
TPOX11
vWA14

Run an STR similarity search on this cell line
Web pages https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
Publications

PubMed=15166400; DOI=10.1093/toxsci/kfh180
Wilson V.S., Bobseine K., Gray L.E. Jr.
Development and characterization of a cell line that stably expresses an estrogen-responsive luciferase reporter for the detection of estrogen receptor agonist and antagonists.
Toxicol. Sci. 81:69-77(2004)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110
Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M., Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S., Huh N., Chung J., Cope L., Fackler M.J., Umbricht C., Sukumar S., Seth P., Sukhatme V.P., Jakkula L.R., Lu Y., Mills G.B., Cho R.J., Collisson E.A., van't Veer L.J., Spellman P.T., Gray J.W.
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:E954893-E954893(2014)

Cross-references
Cell line collections ATCC; CRL-2865
Cell line databases/resources LINCS_HMS; 51091
LINCS_LDP; LCL-2064
Gene expression databases GEO; GSM1172905
GEO; GSM1173001
Other Wikidata; Q54971561
Entry history
Entry creation11-Feb-2013
Last entry update02-Jul-2020
Version number16