Home  |  Contact

Cellosaurus MCF-7/RU58R-1 (CVCL_K235)

[Text version]
Cell line name MCF-7/RU58R-1
Synonyms MCF-7/RU58(R)-1; RU58(R)-1; RU58R-1
Accession CVCL_K235
Resource Identification Initiative To cite this cell line use: MCF-7/RU58R-1 (RRID:CVCL_K235)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:90223; RU 58668.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=15868441; DOI=10.1007/s10549-004-5871-y
Fog C.K., Christensen I.J., Lykkesfeldt A.E.
Characterization of a human breast cancer cell line, MCF-7/RU58R-1, resistant to the pure antiestrogen RU 58,668.
Breast Cancer Res. Treat. 91:133-144(2005)

PubMed=16172194; DOI=10.1677/erc.1.00946
Frogne T., Jepsen J.S., Larsen S.S., Fog C.K., Brockdorff B.L., Lykkesfeldt A.E.
Antiestrogen-resistant human breast cancer cells require activated protein kinase B/Akt for growth.
Endocr. Relat. Cancer 12:599-614(2005)

Cross-references
Cell line databases/resources cancercelllines; CVCL_K235
Encyclopedic resources Wikidata; Q54904378
Entry history
Entry creation11-Feb-2013
Last entry update05-Oct-2023
Version number19