Home  |  Contact

Cellosaurus sNF96.2 (CVCL_K281)

[Text version]
Cell line name sNF96.2
Synonyms SNF96.2; sNF96-2
Accession CVCL_K281
Resource Identification Initiative To cite this cell line use: sNF96.2 (RRID:CVCL_K281)
Comments Doubling time: ~33 hours (ATCC=CRL-2884).
Derived from site: In situ; Peripheral nervous system, lower leg nerve; UBERON=UBERON_0004218.
Cell type: Schwann cell; CL=CL_0002573.
Sequence variations
  • Mutation; HGNC; 7765; NF1; Simple; p.Asn1229Metfs*11 (c.3683delC); Zygosity=Hemizygous (PubMed=17876295).
Disease Malignant peripheral nerve sheath tumor (NCIt: C3798)
Neurofibromatosis type 1 (NCIt: C3273)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Neurofibromatosis type 1 (ORDO: Orphanet_636)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 27Y
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO12
D5S81811
D7S82010,11
D13S31710
D16S53911
TH016
TPOX11
vWA17,19

Run an STR similarity search on this cell line
Web pages https://web.archive.org/web/20150905200621/http://technologylicensing.research.ufl.edu/technologies/11278_human-schwann-cell-like-cell-line-snf96-2
Publications

PubMed=14762442; DOI=10.1038/sj.onc.1207068
Li Y.-W., Rao P.K., Wen R., Song Y., Muir D.F. IV, Wallace P., van Horne S.J., Tennekoon G.I., Kadesch T.
Notch and Schwann cell transformation.
Oncogene 23:1146-1152(2004)

PubMed=17876295; DOI=10.1038/labinvest.3700675
Perrin G.Q., Li H., Fishbein L., Thomson S.A., Hwang M.S., Scarborough M.T., Yachnis A.T., Wallace M.R., Mareci T.H., Muir D.F. IV
An orthotopic xenograft model of intraneural NF1 MPNST suggests a potential association between steroid hormones and tumor cell proliferation.
Lab. Invest. 87:1092-1102(2007)

PubMed=22346343; DOI=10.4137/TOG.S8830
Sun D., Tainsky M.A., Haddad R.
Oncogene mutation survey in MPNST cell lines enhances the dominant role of hyperactive Ras in NF1 associated pro-survival and malignancy.
Transl. Oncogenomics 5:1-7(2012)

PubMed=28469964
Guo J.-M., Grovola M.R., Xie H., Coggins G.E., Duggan P., Hasan R., Huang J.-L., Lin D.W., Song C., Witek G.M., Berritt S., Schultz D.C., Field J.
Comprehensive pharmacological profiling of neurofibromatosis cell lines.
Am. J. Cancer Res. 7:923-934(2017)

PubMed=32642732; DOI=10.1093/noajnl/vdz049
Pemov A., Li H., Presley W., Wallace M.R., Miller D.T.
Genetics of human malignant peripheral nerve sheath tumors.
Neurooncol. Adv. 2:I50-I61(2020)

Cross-references
Cell line collections (Providers) ATCC; CRL-2884
Biological sample resources BioSample; SAMN03471810
Encyclopedic resources Wikidata; Q54955059
Polymorphism and mutation databases Cosmic; 1644553
Entry history
Entry creation11-Feb-2013
Last entry update29-Jun-2023
Version number19