Cellosaurus logo
expasy logo

Cellosaurus MCF-7/AdVp3000 (CVCL_KS20)

[Text version]
Cell line name MCF-7/AdVp3000
Synonyms MCF-7 AdVp3000; MCF AdVp3000
Accession CVCL_KS20
Resource Identification Initiative To cite this cell line use: MCF-7/AdVp3000 (RRID:CVCL_KS20)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 74; ABCG2; Simple; p.Arg482Thr (c.1445G>C); Zygosity=Unspecified (PubMed=11559526).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4Y46 (MCF-7/AdrVp)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=9178101; DOI=10.1002/(SICI)1097-4644(19970615)65:4<513::AID-JCB7>3.0.CO;2-R
Lee J.S., Scala S., Matsumoto Y., Dickstein B., Robey R., Zhan Z.-R., Altenberg G., Bates S.E.
Reduced drug accumulation and multidrug resistance in human breast cancer cells without associated P-glycoprotein or MRP overexpression.
J. Cell. Biochem. 65:513-526(1997)

PubMed=9892175
Miyake K., Mickley L.A., Litman T., Zhan Z.-R., Robey R.W., Cristensen B., Brangi M., Greenberger L.M., Dean M., Fojo T., Bates S.E.
Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes.
Cancer Res. 59:8-13(1999)

PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X
Robey R.W., Honjo Y., van de Laar A., Miyake K., Regis J.T., Litman T., Bates S.E.
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).
Biochim. Biophys. Acta 1512:171-182(2001)

PubMed=11559526
Honjo Y., Hrycyna C.A., Yan Q.-W., Medina-Perez W.Y., Robey R.W., van de Laar A., Litman T., Dean M., Bates S.E.
Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.
Cancer Res. 61:6635-6639(2001)

PubMed=12116365; DOI=10.1002/cyto.10111
Minderman H., Suvannasankha A., O'Loughlin K.L., Scheffer G.L., Scheper R.J., Robey R.W., Baer M.R.
Flow cytometric analysis of breast cancer resistance protein expression and function.
Cytometry 48:59-65(2002)

PubMed=15901850; DOI=10.1124/mol.105.011015
Liu Y., Peng H., Zhang J.-T.
Expression profiling of ABC transporters in a drug-resistant breast cancer cell line using AmpArray.
Mol. Pharmacol. 68:430-438(2005)

Cross-references
Cell line databases/resources cancercelllines; CVCL_KS20
Encyclopedic resources Wikidata; Q54904352
Entry history
Entry creation22-Aug-2017
Last entry update05-Oct-2023
Version number11