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Cellosaurus HepG2 Tet-Off Advanced (CVCL_KU36)

[Text version]

Cell line name HepG2 Tet-Off Advanced
Accession CVCL_KU36
Resource Identification Initiative To cite this cell line use: HepG2 Tet-Off Advanced (RRID:CVCL_KU36)
Comments Population: Caucasian.
Characteristics: Transfected with an advanced tetracycline transactivator (tTA2(S)-M2) protein, a fusion of a mutated E.coli tetR with the activation domain of HSV-1 VP16.
Transfected with: UniProtKB; P04483; E.coli Tn10 tetR.
Transfected with: UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (with del 1-360).
Derived from sampling site: Liver.
Sequence variations Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Web pages http://www.clontech.com/xxclt_ibcGetAttachment.jsp?cItemId=27429
Other Wikidata; Q54882846
Entry history
Entry creation22-Aug-2017
Last entry update20-May-2021
Version number10