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Cellosaurus MCF7 Tet-Off advanced (CVCL_KU37)

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Cell line name MCF7 Tet-Off advanced
Synonyms MCF-7 Tet-Off advanced
Accession CVCL_KU37
Resource Identification Initiative To cite this cell line use: MCF7 Tet-Off advanced (RRID:CVCL_KU37)
Comments Characteristics: Transfected with an advanced tetracycline transactivator (tTA2(S)-M2) protein, a fusion of a mutated E.coli tetR with the activation domain of HSV-1 VP16.
Transfected with: UniProtKB; P04483; E.coli Tn10 tetR.
Transfected with: UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (with del 1-360).
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Web pages http://www.clontech.com/US/Products/Inducible_Systems/Tetracycline-Inducible_Expression/ibcGetAttachment.jsp?cItemId=26905
Other Wikidata; Q54904452
Entry history
Entry creation22-Aug-2017
Last entry update02-Jul-2020
Version number5