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Cellosaurus PathHunter HEK 293 EDG1 Total GPCR Internalization (CVCL_KZ45)

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Cell line name PathHunter HEK 293 EDG1 Total GPCR Internalization
Synonyms PathHunter EDG1 Total GPCR Internalization HEK 293
Accession CVCL_KZ45
Resource Identification Initiative To cite this cell line use: PathHunter HEK 293 EDG1 Total GPCR Internalization (RRID:CVCL_KZ45)
Comments Characteristics: PathHunter total GPCR internalization cell lines co-express a tagged with a beta-galactosidase fragment (ProLink=PK) and a second beta-galactosidase fragment (Enzyme Acceptor=EA) localized to the endosomes. Activation of the GPCR-PK induces internalization of the receptor in EA-tagged endosomes and complementation of the PK and EA enzyme fragments thus resulting into a catalytically active enzyme that generate a chemiluminescent signal.
Transfected with: HGNC; 3165; S1PR1.
Transformant: NCBI_TaxID; 28285; Adenovirus 5.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0045 (HEK293)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
Cell line collections DiscoverX; 93-0784C1
Other Wikidata; Q54938025
Entry history
Entry creation22-Aug-2017
Last entry update07-Sep-2018
Version number3