Home  |  Contact

Cellosaurus JHC7 (CVCL_L154)

[Text version]
Cell line name JHC7
Synonyms Johns Hopkins Chordoma line 7
Accession CVCL_L154
Resource Identification Initiative To cite this cell line use: JHC7 (RRID:CVCL_L154)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Doubling time: ~5 days (PubMed=21699479); 3.5-4 days (Chordoma_Foundation).
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: Genome sequenced.
Omics: Transcriptome analysis by RNAseq.
Anecdotal: Established in 2009 from a chordoma tumor sample originating from Susan L. Garbett who wrote about her successful fight against cancer in an autobiographical book (CelloPub=CLPUB00390).
Derived from site: In situ; Bone, sacrum; UBERON=UBERON_0003690.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg213Leu (c.638G>T); ClinVar=VCV000376650; Zygosity=Unspecified (DepMap).
HLA typing Source: Chordoma_Foundation
Class I
HLA-AA*24
Disease Sacral chordoma (NCIt: C129927)
Chordoma (ORDO: Orphanet_178)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 61Y
Category Cancer cell line
STR profile Source(s): ATCC; PubMed=27102572; PubMed=28835717

Markers:
AmelogeninX
CSF1PO11
D2S133818,20
D3S135817
D5S81813
D7S8207,10
D8S117913,14
D13S31711
D16S53911
D18S5112
D19S43313,13.2
D21S1127,31.2
FGA21,23
Penta D6,11
Penta E15
TH016,8
TPOX10,11
vWA17

Run an STR similarity search on this cell line
Web pages https://www.chordomafoundation.org/research/disease-models/jhc7/
https://www.youtube.com/watch?v=6w-iamlS8k8
Publications

PubMed=21699479; DOI=10.3171/2011.5.JNS11185
Hsu W., Mohyeldin A., Shah S.R., ap Rhys C.M.J., Johnson L.F., Sedora-Roman N.I., Kosztowski T.A., Awad O.A., McCarthy E.F., Loeb D.M., Wolinsky J.-P., Gokaslan Z.L., Quinones-Hinojosa A.
Generation of chordoma cell line JHC7 and the identification of Brachyury as a novel molecular target.
J. Neurosurg. 115:760-769(2011)

CLPUB00390
Garbett S.L.
Confronting chordoma cancer. An uncommon journey.
(In) ISBN 9780983617198; pp.1-264; Parquetry Press; Tallevast (2015)

PubMed=27102572; DOI=10.1002/path.4729
Scheipl S., Barnard M., Cottone L., Jorgensen M., Drewry D.H., Zuercher W.J., Turlais F., Ye H.-T., Leite A.P., Smith J.A., Leithner A., Moller P., Bruderlein S., Guppy N., Amary F., Tirabosco R., Strauss S.J., Pillay N., Flanagan A.M.
EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen.
J. Pathol. 239:320-334(2016)

PubMed=28835717; DOI=10.1038/s41598-017-10044-3
Bosotti R., Magnaghi P., Di Bella S., Cozzi L., Cusi C., Bozzi F., Beltrami N., Carapezza G., Ballinari D., Amboldi N., Lupi R., Somaschini A., Raddrizzani L., Salom B., Galvani A., Stacchiotti S., Tamborini E., Isacchi A.
Establishment and genomic characterization of the new chordoma cell line Chor-IN-1.
Sci. Rep. 7:9226-9226(2017)

Cross-references
Cell line collections (Providers) ATCC; CRL-3267
Cell line databases/resources cancercelllines; CVCL_L154
Cell_Model_Passport; SIDM01802
DepMap; ACH-001955
Encyclopedic resources Wikidata; Q54898635
Polymorphism and mutation databases Cosmic; 2663862
Entry history
Entry creation06-May-2013
Last entry update05-Oct-2023
Version number22