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Cellosaurus CMT12 (CVCL_L329)

[Text version]

Cell line name CMT12
Synonyms CMT-12; Canine Mammary Tumor 12
Accession CVCL_L329
Resource Identification Initiative To cite this cell line use: CMT12 (RRID:CVCL_L329)
Comments Part of: FACC canine tumor cell line panel.
Doubling time: 19 hours (PubMed=27257868).
Omics: Deep exome analysis.
Omics: Transcriptome analysis.
Caution: On the basis of STR profile (PubMed=21908323; PubMed=27197945) CMT12 and CMT27 seem to originate from the same donor.
Sequence variations
  • Mutation; VGNC; 42490; KMT2C; Simple; p.Arg1201fs (c.3600delGinsAA); Zygosity=Homozygous (PubMed=31175136).
  • Mutation; VGNC; 47719; TP53; Simple; p.Val132Glu (c.395T>A); Zygosity=Homozygous (PubMed=31175136).
Disease Canine mammary carcinoma (NCIt: C124249)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Originate from same individual CVCL_1R41 ! CMT27
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=27197945; PubMed=31175136

Dog FHC2010235
Dog FHC2054151,176
Dog FHC2079271
Dog PEZ1115
Dog PEZ12277
Dog PEZ20176
Dog PEZ3113,119
Dog PEZ5103
Dog PEZ6176
Dog PEZ8233,244

Run an STR similarity search on this cell line

PubMed=19130492; DOI=10.1002/jcb.22034
DeInnocentes P., Agarwal P., Bird R.C.
Phenotype-rescue of cyclin-dependent kinase inhibitor p16/INK4A defects in a spontaneous canine cell model of breast cancer.
J. Cell. Biochem. 106:491-505(2009)

PubMed=21801068; DOI=10.2460/ajvr.72.8.1097
Stokol T., Daddona J.L., Mubayed L.S., Trimpert J., Kang S.-K.
Evaluation of tissue factor expression in canine tumor cells.
Am. J. Vet. Res. 72:1097-1106(2011)

PubMed=21908323; DOI=10.1177/1040638711408064
O'Donoghue L.E., Rivest J.P., Duval D.L.
Polymerase chain reaction-based species verification and microsatellite analysis for canine cell line validation.
J. Vet. Diagn. Invest. 23:780-785(2011)

PubMed=23238983; DOI=10.1002/jcb.24476
Agarwal P., Sandey M., DeInnocentes P., Bird R.C.
Tumor suppressor gene p16/INK4A/CDKN2A-dependent regulation into and out of the cell cycle in a spontaneous canine model of breast cancer.
J. Cell. Biochem. 114:1355-1363(2013)

PubMed=27257868; DOI=10.1371/journal.pone.0156689
Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.
Intrinsic radiosensitivity and cellular characterization of 27 canine cancer cell lines.
PLoS ONE 11:E0156689-E0156689(2016)

PubMed=27197945; DOI=10.1111/vco.12192
Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.
The Flint Animal Cancer Center (FACC) canine tumour cell line panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
Vet. Comp. Oncol. 15:481-492(2017)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346
Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.
Identifying candidate druggable targets in canine cancer cell lines using whole exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

Encyclopedic resources Wikidata; Q54813839
Gene expression databases GEO; GSM1974783
Entry history
Entry creation06-May-2013
Last entry update20-May-2021
Version number14