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Cellosaurus KE 37.3.2 (CVCL_L699)

[Text version]
Cell line name KE 37.3.2
Synonyms KE37.3.2; KE37 3.2
Accession CVCL_L699
Resource Identification Initiative To cite this cell line use: KE 37.3.2 (RRID:CVCL_L699)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
Transformant: ChEBI; CHEBI:23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
Sequence variations
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Gln2459Ter (c.7375C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9585; PTCH1; Simple; p.Arg571Gln (c.1712G>A); ClinVar=VCV000819886; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9884; RB1; Simple; p.Gly310Glu (c.929G>A); ClinVar=VCV000237678; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro153Alafs*28 (c.455dupC) (c.455_456insC) (p.P152fs) (c.459_460insC); ClinVar=VCV000182958; Zygosity=Heterozygous (from parent cell line).
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1327 (KE-37)
Children:
CVCL_L696 (HM 1)CVCL_3713 (HM 2)CVCL_L697 (SK 7)
CVCL_L698 (SK 8)
Sex of cell Male
Age at sampling 27Y
Category Cancer cell line
Publications

PubMed=6983562; DOI=10.1084/jem.156.6.1860
Mayer L., Fu S.-M., Kunkel H.G.
Human T cell hybridomas secreting factors for IgA-specific help, polyclonal B cell activation, and B cell proliferation.
J. Exp. Med. 156:1860-1865(1982)

Cross-references
Cell line databases/resources cancercelllines; CVCL_L699
Encyclopedic resources Wikidata; Q54899711
Entry history
Entry creation06-May-2013
Last entry update05-Oct-2023
Version number14