ID   AG05397
AC   CVCL_L780
SY   AG5397
DR   CLO; CLO_0035217
DR   Coriell; AG05397
DR   Wikidata; Q54739981
RX   CelloPub=CLPUB00597;
RX   PubMed=17668376;
RX   PubMed=18691744;
RX   PubMed=23716668;
RX   PubMed=24119401;
CC   Population: Caucasian.
CC   Derived from site: In situ; Chest, skin; UBERON=UBERON_0001868.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
DI   NCIt; C2993; Down syndrome
DI   ORDO; Orphanet_870; Down syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   1Y
CA   Finite cell line
DT   Created: 06-05-13; Last updated: 29-06-23; Version: 17
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RX   CelloPub=CLPUB00597;
RG   National Institute on Aging;
RT   "1994 catalog of cell lines. NIA Aging Cell Repository.";
RL   (In) Institute for Medical Research (Camden, N.J.); pp.1-351; National Institutes of Health; Bethesda (1994).
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RX   PubMed=17668376; DOI=10.1086/519248;
RA   Prandini P., Deutsch S., Lyle R., Gagnebin M., Delucinge-Vivier C.,
RA   Delorenzi M., Gehrig C., Descombes P., Sherman S.L.,
RA   Dagna-Bricarelli F., Baldo C., Novelli A., Dallapiccola B.,
RA   Antonarakis S.E.;
RT   "Natural gene-expression variation in Down syndrome modulates the
RT   outcome of gene-dosage imbalance.";
RL   Am. J. Hum. Genet. 81:252-263(2007).
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RX   PubMed=18691744; DOI=10.1016/j.cell.2008.07.041;
RA   Park I.-H., Arora N., Huo H.-G., Maherali N., Ahfeldt T., Shimamura A.,
RA   Lensch M.W., Cowan C.A., Hochedlinger K., Daley G.Q.;
RT   "Disease-specific induced pluripotent stem cells.";
RL   Cell 134:877-886(2008).
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RX   PubMed=23716668; DOI=10.1073/pnas.1216575110;
RA   Weick J.P., Held D.L., Bonadurer G.F. III, Doers M.E., Liu Y.,
RA   Maguire C., Clark A., Knackert J.A., Molinarolo K., Musser M.T., Yao L.,
RA   Yin Y.-N., Lu J.-F., Zhang X.-Q., Zhang S.-C., Bhattacharyya A.;
RT   "Deficits in human trisomy 21 iPSCs and neurons.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:9962-9967(2013).
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RX   PubMed=24119401; DOI=10.1016/j.molcel.2013.09.009;
RA   Chen J.-Y., Lin J.-R., Tsai F.-C., Meyer T.;
RT   "Dosage of Dyrk1a shifts cells within a p21-cyclin D1 signaling map to
RT   control the decision to enter the cell cycle.";
RL   Mol. Cell 52:87-100(2013).
//