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Cellosaurus Hep-G2/2.2.15 (CVCL_L855)

[Text version]

Cell line name Hep-G2/2.2.15
Synonyms HEP-G2/2.2.15; Hep-G2/2215; HepG2-2.2.15; HepG2 2.2.15; HepG2.2.15; HepG2(2.2.15); 2.2.15
Accession CVCL_L855
Resource Identification Initiative To cite this cell line use: Hep-G2/2.2.15 (RRID:CVCL_L855)
Comments Characteristics: Contains 2 head to tails stably integrated HBV of the D-genotype.
Sequence variations NRAS p.Gln61Leu (c.182A>T) (ClinVar=VCV000375874) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line

PubMed=3029758; DOI=10.1073/pnas.84.4.1005
Sells M.A., Chen M.L., Acs G.
Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA.
Proc. Natl. Acad. Sci. U.S.A. 84:1005-1009(1987)

PubMed=21448419; DOI=10.3748/wjg.v17.i9.1152
Zhao R., Wang T.-Z., Kong D., Zhang L., Meng H.-X., Jiang Y., Wu Y.-Q., Yu Z.-X., Jin X.-M.
Hepatoma cell line HepG2.2.15 demonstrates distinct biological features compared with parental HepG2.
World J. Gastroenterol. 17:1152-1159(2011)

PubMed=29481805; DOI=10.1016/j.bbrc.2018.02.175
Ogura N., Ogawa K., Watashi K., Ito T., Wakita T.
Novel stable HBV producing cell line systems for expression and screening antiviral inhibitor of hepatitis B virus in human hepatoma cell line.
Biochem. Biophys. Res. Commun. 498:64-71(2018)

Cell line collections CCTCC; GDC0141
Cell line databases/resources CLDB; cl33
Ontologies BTO; BTO:0005621
CLO; CLO_0001176
Chemistry resources ChEMBL-Cells; CHEMBL3833241
Other Wikidata; Q54882787
Polymorphism and mutation databases Cosmic; 979733
Entry history
Entry creation06-May-2013
Last entry update02-Jul-2020
Version number15