ID   Hep-G2/2.2.15
AC   CVCL_L855
SY   HEP-G2/2.2.15; Hep-G2/2215; HepG2/2215; HepG2-2.2.15; HepG2 2.2.15; HepG2.2.15; HepG2(2.2.15); 2.2.15
DR   BTO; BTO:0005621
DR   CLO; CLO_0001176
DR   CLDB; cl33
DR   cancercelllines; CVCL_L855
DR   ChEMBL-Cells; CHEMBL3833241
DR   ChEMBL-Targets; CHEMBL4296438
DR   CCTCC; GDC0141
DR   Cosmic; 979733
DR   Millipore; SCC249
DR   PubChem_Cell_line; CVCL_L855
DR   Wikidata; Q54882787
RX   PubMed=3029758;
RX   PubMed=8224613;
RX   PubMed=21448419;
RX   PubMed=29481805;
CC   Population: Caucasian.
CC   Virology: Contains 2 head to tails stably integrated hepatitis B virus (HBV) of the D-genotype.
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
ST   Source(s): Millipore
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 9,13
ST   D16S539: 12,13
ST   D18S51: 13,14
ST   D21S11: 29,31
ST   D3S1358: 15,16
ST   D5S818: 11,12
ST   D7S820: 10
ST   D8S1179: 15,16
ST   FGA: 22,25
ST   Penta D: 9,13
ST   Penta E: 15,20
ST   TH01: 9
ST   TPOX: 8,9
ST   vWA: 17
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0027 ! Hep-G2
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 06-05-13; Last updated: 05-10-23; Version: 22
//
RX   PubMed=3029758; DOI=10.1073/pnas.84.4.1005;
RA   Sells M.A., Chen M.-L., Acs G.;
RT   "Production of hepatitis B virus particles in Hep G2 cells transfected
RT   with cloned hepatitis B virus DNA.";
RL   Proc. Natl. Acad. Sci. U.S.A. 84:1005-1009(1987).
//
RX   PubMed=8224613; DOI=10.1096/fasebj.7.14.8224613;
RA   Puisieux A., Galvin K., Troalen F., Bressac B., Marcais C., Galun E.,
RA   Ponchel F., Yakicier C., Ji J.-W., Ozturk M.;
RT   "Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell
RT   lines.";
RL   FASEB J. 7:1407-1413(1993).
//
RX   PubMed=21448419; DOI=10.3748/wjg.v17.i9.1152;
RA   Zhao R., Wang T.-Z., Kong D., Zhang L., Meng H.-X., Jiang Y., Wu Y.-Q.,
RA   Yu Z.-X., Jin X.-M.;
RT   "Hepatoma cell line HepG2.2.15 demonstrates distinct biological
RT   features compared with parental HepG2.";
RL   World J. Gastroenterol. 17:1152-1159(2011).
//
RX   PubMed=29481805; DOI=10.1016/j.bbrc.2018.02.175;
RA   Ogura N., Ogawa K., Watashi K., Ito T., Wakita T.;
RT   "Novel stable HBV producing cell line systems for expression and
RT   screening antiviral inhibitor of hepatitis B virus in human hepatoma
RT   cell line.";
RL   Biochem. Biophys. Res. Commun. 498:64-71(2018).
//