ID   GM02504
AC   CVCL_L976
SY   GM-2504; GM 2504; GM02504H; GM00258; GM-258; GM258
DR   CLO; CLO_0033251
DR   Coriell; GM00258
DR   Coriell; GM02504
DR   Wikidata; Q54837524
RX   CelloPub=CLPUB00447;
RX   DOI=10.5962/bhl.title.4090;
RX   PubMed=291901;
RX   PubMed=694721;
RX   PubMed=6159644;
RX   PubMed=6160588;
RX   PubMed=6179471;
RX   PubMed=7299037;
RX   PubMed=17668376;
RX   PubMed=23716668;
CC   Population: African American.
CC   Discontinued: Coriell; GM00258; true.
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
DI   NCIt; C2993; Down syndrome
DI   ORDO; Orphanet_870; Down syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   1M
CA   Finite cell line
DT   Created: 06-05-13; Last updated: 29-06-23; Version: 20
//
RX   CelloPub=CLPUB00447;
RA   Mulivor R.A., Suchy S.F.;
RT   "1992/1993 catalog of cell lines. NIGMS human genetic mutant cell
RT   repository. 16th edition. October 1992.";
RL   (In) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda (1992).
//
RX   DOI=10.5962/bhl.title.4090;
RA   Coriell L.L., Greene A.E.;
RT   "The human genetic mutant cell repository: list of genetic variants,
RT   chromosomal aberrations and normal cell cultures submitted to the
RT   repository. 4th edition. October 1977.";
RL   (In) Institute for Medical Research (Camden, N.J.); pp.1-171; National Institutes of Health; Bethesda (1977).
//
RX   PubMed=291901; DOI=10.1073/pnas.76.10.4817;
RA   Gupta S.L., Rubin B.Y., Holmes S.L.;
RT   "Interferon action: induction of specific proteins in mouse and human
RT   cells by homologous interferons.";
RL   Proc. Natl. Acad. Sci. U.S.A. 76:4817-4821(1979).
//
RX   PubMed=694721; DOI=10.1007/BF01542843;
RA   Chen Y.-T., Worthy T.E., Krooth R.S.;
RT   "Evidence for a striking increase in acetylcholinesterase activity in
RT   cultured human fibroblasts which are trisomic for chromosome two.";
RL   Somatic Cell Genet. 4:265-298(1978).
//
RX   PubMed=6159644; DOI=10.1073/pnas.77.9.5341;
RA   Pang R.H.L., Hayes T.G., Vilcek J.T.;
RT   "Le interferon mRNA from human fibroblasts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 77:5341-5345(1980).
//
RX   PubMed=6160588; DOI=10.1073/pnas.77.10.5938;
RA   Pickering L.A., Kronenberg L.H., Stewart W.E. II;
RT   "Spontaneous production of human interferon.";
RL   Proc. Natl. Acad. Sci. U.S.A. 77:5938-5942(1980).
//
RX   PubMed=6179471; DOI=10.1016/0166-3542(82)90029-8;
RA   De Ley M., Billiau A.;
RT   "Responsiveness of human cells trisomic for chromosome 21 to the
RT   antiviral action of human immune interferon.";
RL   Antiviral Res. 2:97-102(1982).
//
RX   PubMed=7299037; DOI=10.1016/0165-022X(81)90016-6;
RA   Sorbi S., Blass J.P.;
RT   "Spectrophotometric measurement of pyruvate dehydrogenase complex
RT   activity in cultured human fibroblasts.";
RL   J. Biochem. Biophys. Methods 5:169-176(1981).
//
RX   PubMed=17668376; DOI=10.1086/519248;
RA   Prandini P., Deutsch S., Lyle R., Gagnebin M., Delucinge-Vivier C.,
RA   Delorenzi M., Gehrig C., Descombes P., Sherman S.L.,
RA   Dagna-Bricarelli F., Baldo C., Novelli A., Dallapiccola B.,
RA   Antonarakis S.E.;
RT   "Natural gene-expression variation in Down syndrome modulates the
RT   outcome of gene-dosage imbalance.";
RL   Am. J. Hum. Genet. 81:252-263(2007).
//
RX   PubMed=23716668; DOI=10.1073/pnas.1216575110;
RA   Weick J.P., Held D.L., Bonadurer G.F. III, Doers M.E., Liu Y.,
RA   Maguire C., Clark A., Knackert J.A., Molinarolo K., Musser M.T., Yao L.,
RA   Yin Y.-N., Lu J.-F., Zhang X.-Q., Zhang S.-C., Bhattacharyya A.;
RT   "Deficits in human trisomy 21 iPSCs and neurons.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:9962-9967(2013).
//