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Cellosaurus PathHunter U2OS GPR22 beta-arrestin (CVCL_LA42)

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Cell line name PathHunter U2OS GPR22 beta-arrestin
Accession CVCL_LA42
Resource Identification Initiative To cite this cell line use: PathHunter U2OS GPR22 beta-arrestin (RRID:CVCL_LA42)
Comments Characteristics: PathHunter beta-arrestin cell lines co-express a GPCR tagged with a beta-galactosidase fragment (ProLink=PK) and a beta-arrestin tagged with another fragment (Enzyme Acceptor=EA). Activation of the GPCR-PK induces beta-arrestin-EA recruitment and complementation of the PK and EA enzyme fragments thus resulting into a catalytically active enzyme that generate a chemiluminescent signal.
Transfected with: HGNC; 4477; GPR22.
Transfected with: HGNC; 712; ARRB2.
Derived from sampling site: Bone; tibia.
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Cell line collections DiscoverX; 93-1085C3
Other Wikidata; Q54938167
Entry history
Entry creation22-Aug-2017
Last entry update12-Mar-2020
Version number4