| Cell line name | PathHunter U2OS IkappaB Degradation |
|---|---|
| Accession | CVCL_LA63 |
| Resource Identification Initiative | To cite this cell line use: PathHunter U2OS IkappaB Degradation (RRID:CVCL_LA63) |
| Comments | Population: Caucasian. Characteristics: PathHunter degradation cell lines express a target protein tagged with a beta-galactosidase fragment (Enzyme Donor=ED). Pathway activation results in the degradation of the target protein. The degraded protein is detected by adding to the cell lysis buffer another beta-galactosidase fragment (Enzyme Acceptor=EA). Complementation of the ED and EA enzyme fragments result into a catalytically active enzyme that generate a chemiluminescent signal. Transfected with: HGNC; 7797; NFKBIA. Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979. |
| Sequence variations |
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| Disease | Osteosarcoma (NCIt: C9145) Osteosarcoma (ORDO: Orphanet_668) |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Hierarchy | Parent: CVCL_0042 (U2OS) |
| Sex of cell | Female |
| Age at sampling | 15Y |
| Category | Cancer cell line |
| Cross-references | |
| Cell line collections (Providers) | DiscoverX; 93-0538C3 |
| Encyclopedic resources | Wikidata; Q54938191 |
| Entry history | |
| Entry creation | 22-Aug-2017 |
| Last entry update | 05-Oct-2023 |
| Version number | 9 |