| Cell line name | PathHunter U2OS PTGIR Total GPCR Internalization |
|---|---|
| Synonyms | PathHunter PTGIR Total GPCR Internalization U2OS |
| Accession | CVCL_LB23 |
| Resource Identification Initiative | To cite this cell line use: PathHunter U2OS PTGIR Total GPCR Internalization (RRID:CVCL_LB23) |
| Comments | Characteristics: PathHunter total GPCR internalization cell lines co-express a tagged with a beta-galactosidase fragment (ProLink=PK) and a second beta-galactosidase fragment (Enzyme Acceptor=EA) localized to the endosomes. Activation of the GPCR-PK induces internalization of the receptor in EA-tagged endosomes and complementation of the PK and EA enzyme fragments thus resulting into a catalytically active enzyme that generate a chemiluminescent signal. Transfected with: HGNC; 9602; PTGIR. Derived from sampling site: Bone; tibia. |
| Disease | Osteosarcoma (NCIt: C9145) Osteosarcoma (ORDO: Orphanet_668) |
| Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
|
| Hierarchy | Parent: CVCL_0042 (U2OS) |
| Sex of cell | Female |
| Age at sampling | 15Y |
| Category | Cancer cell line |
| Cross-references | |
| Cell line collections | DiscoverX; 93-0838C3 |
| Other | Wikidata; Q54938282 |
| Entry history | |
| Entry creation | 22-Aug-2017 |
| Last entry update | 12-Mar-2020 |
| Version number | 4 |