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Cellosaurus MCF-7 MX8 (CVCL_LB50)

[Text version]

Cell line name MCF-7 MX8
Synonyms MCF MX8; MCF-MX8; MCF MX-8
Accession CVCL_LB50
Resource Identification Initiative To cite this cell line use: MCF-7 MX8 (RRID:CVCL_LB50)
Comments Selected for resistance to: ChEBI; CHEBI:50729; Mitoxantrone.
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line

PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X
Robey R.W., Honjo Y., van de Laar A., Miyake K., Regis J.T., Litman T., Bates S.E.
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).
Biochim. Biophys. Acta 1512:171-182(2001)

Honjo Y., Hrycyna C.A., Yan Q.-W., Medina-Perez W.Y., Robey R.W., van de Laar A., Litman T., Dean M., Bates S.E.
Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.
Cancer Res. 61:6635-6639(2001)

PubMed=12116365; DOI=10.1002/cyto.10111
Minderman H., Suvannasankha A., O'Loughlin K.L., Scheffer G.L., Scheper R.J., Robey R.W., Baer M.R.
Flow cytometric analysis of breast cancer resistance protein expression and function.
Cytometry 48:59-65(2002)

Other Wikidata; Q54904321
Entry history
Entry creation22-Aug-2017
Last entry update02-Jul-2020
Version number5