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Cellosaurus MCF-7 MX20 (CVCL_LB51)

[Text version]

Cell line name MCF-7 MX20
Accession CVCL_LB51
Resource Identification Initiative To cite this cell line use: MCF-7 MX20 (RRID:CVCL_LB51)
Comments Selected for resistance to: ChEBI; CHEBI:50729; Mitoxantrone.
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Children:
CVCL_LB52 (MCF-7 MX40)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X
Robey R.W., Honjo Y., van de Laar A., Miyake K., Regis J.T., Litman T., Bates S.E.
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).
Biochim. Biophys. Acta 1512:171-182(2001)

Cross-references
Other Wikidata; Q54904319
Entry history
Entry creation22-Aug-2017
Last entry update02-Jul-2020
Version number5