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Cellosaurus KM12 MX10 (CVCL_LB66)

Cell line name KM12 MX10
Accession CVCL_LB66
Resource Identification Initiative To cite this cell line use: KM12 MX10 (RRID:CVCL_LB66)
Comments Selected for resistance to: ChEBI; CHEBI:50729; Mitoxantrone.
Sequence variations Homozygous for ACVR2A p.Lys437fs*5 (c.1310delA) (from parent cell line).
Heterozygous for APC p.Asn1819fs*7 (c.5454_5455insA) (from parent cell line).
Heterozygous for BRCA2 p.Asn1784Hisfs*7 (c.5350_5351delAA) (from parent cell line).
Heterozygous for PTEN p.Gly129Ter (c.385G>T) and p.Lys267fs*9 (c.800delA) (from parent cell line).
Heterozygous for TGFBR2 p.Lys128Serfs*35 (c.383delA) (from parent cell line).
Heterozygous for TP53 p.Arg72fs*51 (c.215delG) (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1331 (KM12)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X
Robey R.W., Honjo Y., van de Laar A., Miyake K., Regis J.T., Litman T., Bates S.E.
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).
Biochim. Biophys. Acta 1512:171-182(2001)

Cross-references
Other Wikidata; Q54900053