Cellosaurus NCI-H460 MX10 (CVCL_LB67)

Cell line name NCI-H460 MX10
Synonyms H460 MX10
Accession CVCL_LB67
Resource Identification Initiative To cite this cell line use: NCI-H460 MX10 (RRID:CVCL_LB67)
Comments Selected for resistance to: ChEBI; CHEBI:50729; Mitoxantrone.
Sequence variation: Homozygous for KRAS p.Gln61His (from parent cell line).
Sequence variation: Heterozygous for PIK3CA p.Glu545Lys (from parent cell line).
Sequence variation: Homozygous for STK11 p.Gln37Ter (from parent cell line).
Disease Large cell lung carcinoma (NCIt: C4450)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0459 (NCI-H460)
Sex of cell Male
Category Cancer cell line
Publications

PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X
Robey R.W., Honjo Y., van de Laar A., Miyake K., Regis J.T., Litman T., Bates S.E.
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).
Biochim. Biophys. Acta 1512:171-182(2001)

PubMed=11559526
Honjo Y., Hrycyna C.A., Yan Q.-W., Medina-Perez W.Y., Robey R.W., van de Laar A., Litman T., Dean M., Bates S.E.
Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.
Cancer Res. 61:6635-6639(2001)