Cellosaurus NCI-H460 MX10 (CVCL_LB67)

Cell line name NCI-H460 MX10
Synonyms H460 MX10
Accession CVCL_LB67
Resource Identification Initiative To cite this cell line use: NCI-H460 MX10 (RRID:CVCL_LB67)
Comments Selected for resistance to: ChEBI; CHEBI:50729; Mitoxantrone.
Sequence variations Homozygous for KRAS p.Gln61His (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (from parent cell line).
Homozygous for STK11 p.Gln37Ter (from parent cell line).
Disease Large cell lung carcinoma (NCIt: C4450)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0459 (NCI-H460)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X
Robey R.W., Honjo Y., van de Laar A., Miyake K., Regis J.T., Litman T., Bates S.E.
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).
Biochim. Biophys. Acta 1512:171-182(2001)

PubMed=11559526
Honjo Y., Hrycyna C.A., Yan Q.-W., Medina-Perez W.Y., Robey R.W., van de Laar A., Litman T., Dean M., Bates S.E.
Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.
Cancer Res. 61:6635-6639(2001)