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Cellosaurus LIM1215 KRAS (G12R/+) (CVCL_LC76)

[Text version]
Cell line name LIM1215 KRAS (G12R/+)
Synonyms KRAS (G12R/+) LIM1215
Accession CVCL_LC76
Resource Identification Initiative To cite this cell line use: LIM1215 KRAS (G12R/+) (RRID:CVCL_LC76)
Comments Population: Caucasian.
Characteristics: Heterozygous knockin of a KRAS activating mutation.
Derived from site: Metastatic; Omentum; UBERON=UBERON_0003688.
Sequence variations
  • Mutation; HGNC; 173; ACVR2A; Simple; p.Pro423Gln (c.1268C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Thr41Ala (c.121A>G); ClinVar=VCV000017580; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple_edited; p.Gly12Arg (c.34G>C); ClinVar=VCV000012579; Zygosity=Heterozygous; Note=By method not specified (Horizon_Discovery=HD+116-002).
  • Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Lynch syndrome (NCIt: C8494)
Lynch syndrome (ORDO: Orphanet_144)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2574 (LIM1215)
Sex of cell Male
Age at sampling 34Y
Category Cancer cell line
Publications

PubMed=22722830; DOI=10.1038/nature11156
Misale S., Yaeger R., Hobor S., Scala E., Janakiraman M., Liska D., Valtorta E., Schiavo R., Buscarino M., Siravegna G., Bencardino K., Cercek A., Chen C.-T., Veronese S., Zanon C., Sartore-Bianchi A., Gambacorta M., Gallicchio M., Vakiani E., Boscaro V., Medico E., Weiser M.R., Siena S., Di Nicolantonio F., Solit D.B., Bardelli A.
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer.
Nature 486:532-536(2012)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+116-002
Cell line databases/resources cancercelllines; CVCL_LC76
Encyclopedic resources Wikidata; Q54902522
Entry history
Entry creation22-Aug-2017
Last entry update30-Jan-2024
Version number13