Cellosaurus LIM1215 KRAS (G13D/+) (CVCL_LC82)

Cell line name LIM1215 KRAS (G13D/+)
Synonyms KRAS (G13D/+) LIM1215
Accession CVCL_LC82
Resource Identification Initiative To cite this cell line use: LIM1215 KRAS (G13D/+) (RRID:CVCL_LC82)
Comments Characteristics: Heterozygous knockin of a KRAS activating mutation.
Sequence variation: CTNNB1 p.Thr41Ala (from parent cell line).
Sequence variation: Heterozygous for KRAS p.Gly13Asp.
Disease Colon adenocarcinoma (NCIt: C4349)
Lynch syndrome (NCIt: C8494)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
Web pages https://www.horizondiscovery.com/human-kras-g13d-lim1215-cell-line-hd-116-009

PubMed=22722830; DOI=10.1038/nature11156
Misale S., Yaeger R., Hobor S., Scala E., Janakiraman M., Liska D., Valtorta E., Schiavo R., Buscarino M., Siravegna G., Bencardino K., Cercek A., Chen C.-T., Veronese S., Zanon C., Sartore-Bianchi A., Gambacorta M., Gallicchio M., Vakiani E., Boscaro V., Medico E., Weiser M., Siena S., Di Nicolantonio F., Solit D., Bardelli A.
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer.
Nature 486:532-536(2012)