ID   LIM1215 KRAS (G13D/+)
AC   CVCL_LC82
SY   KRAS (G13D/+) LIM1215
DR   cancercelllines; CVCL_LC82
DR   Horizon_Discovery; HD+116-009
DR   Wikidata; Q54902525
RX   PubMed=22722830;
CC   Population: Caucasian.
CC   Characteristics: Heterozygous knockin of a KRAS activating mutation.
CC   Sequence variation: Mutation; HGNC; 173; ACVR2A; Simple; p.Pro423Gln (c.1268C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Thr41Ala (c.121A>G); ClinVar=VCV000017580; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple_edited; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous; Note=By method not specified (Horizon_Discovery=HD+116-009).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Omentum; UBERON=UBERON_0003688.
DI   NCIt; C4349; Colon adenocarcinoma
DI   NCIt; C8494; Lynch syndrome
DI   ORDO; Orphanet_144; Lynch syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2574 ! LIM1215
SX   Male
AG   34Y
CA   Cancer cell line
DT   Created: 22-08-17; Last updated: 30-01-24; Version: 14
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RX   PubMed=22722830; DOI=10.1038/nature11156;
RA   Misale S., Yaeger R., Hobor S., Scala E., Janakiraman M., Liska D.,
RA   Valtorta E., Schiavo R., Buscarino M., Siravegna G., Bencardino K.,
RA   Cercek A., Chen C.-T., Veronese S., Zanon C., Sartore-Bianchi A.,
RA   Gambacorta M., Gallicchio M., Vakiani E., Boscaro V., Medico E.,
RA   Weiser M.R., Siena S., Di Nicolantonio F., Solit D.B., Bardelli A.;
RT   "Emergence of KRAS mutations and acquired resistance to anti-EGFR
RT   therapy in colorectal cancer.";
RL   Nature 486:532-536(2012).
//