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Cellosaurus NCI-H1975 KRAS (G12D/+) (CVCL_LC85)

[Text version]
Cell line name NCI-H1975 KRAS (G12D/+)
Synonyms KRAS (G12D/+) NCI-H1975; NCI-H1975 K-RAS(G12D/+)
Accession CVCL_LC85
Resource Identification Initiative To cite this cell line use: NCI-H1975 KRAS (G12D/+) (RRID:CVCL_LC85)
Comments Population: Caucasian.
Characteristics: Heterozygous knockin of a KRAS activating mutation.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple_edited; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous; Note=By method not specified (Horizon_Discovery=HD+120-001).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Gly118Asp (c.353G>A); ClinVar=VCV000156446; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1511 (NCI-H1975)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+120-001
Cell line databases/resources cancercelllines; CVCL_LC85
Encyclopedic resources Wikidata; Q54907892
Entry history
Entry creation22-Aug-2017
Last entry update30-Jan-2024
Version number12