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Cellosaurus NCI-H1975 KRAS (G12D/+) (CVCL_LC85)

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Cell line name NCI-H1975 KRAS (G12D/+)
Synonyms KRAS (G12D/+) NCI-H1975; NCI-H1975 K-RAS(G12D/+)
Accession CVCL_LC85
Resource Identification Initiative To cite this cell line use: NCI-H1975 KRAS (G12D/+) (RRID:CVCL_LC85)
Comments Characteristics: Heterozygous knockin of a KRAS activating mutation.
Sequence variations Heterozygous for KRAS p.Gly12Asp (c.35G>A).
EGFR p.Thr790Met (c.2369C>T) and p.Leu858Arg (c.2573T>G) (from parent cell line).
Heterozygous for PIK3CA p.Gly118Asp (c.353G>A) (from parent cell line).
Homozygous for TP53 p.Arg273His (c.818G>A) (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1511 (NCI-H1975)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Web pages https://www.horizondiscovery.com/kras-g12d-nci-h1975-cell-line-hd-120-001
Other Wikidata; Q54907892
Entry history
Entry creation22-Aug-2017
Last entry updated06-Sep-2019
Version number5