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Cellosaurus A375 NRAS (Q61K/+/+) (CVCL_LC86)

[Text version]

Cell line name A375 NRAS (Q61K/+/+)
Synonyms NRAS (Q61K/+/+) A375
Accession CVCL_LC86
Resource Identification Initiative To cite this cell line use: A375 NRAS (Q61K/+/+) (RRID:CVCL_LC86)
Comments Characteristics: Heterozygous knockin of a NRAS activating mutation.
Sequence variations Heterozygous for NRAS p.Gln61Lys (c.181C>A).
Homozygous for BRAF p.Val600Glu (c.1799T>A) (from parent cell line).
Homozygous for CDKN2A p.Glu61Ter (c.181G>T) (p.Gly75Val; c.224G>T) and p.Glu69Ter (c.205G>T) (p.Gly83Val; c.248G>T) (from parent cell line).
TERT c.250C>T (-146C>T); in promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Web pages https://www.horizondiscovery.com/nras-q61k-a375-cell-line-hd-118-001
Other Wikidata; Q54606773
Entry history
Entry creation22-Aug-2017
Last entry updated05-Jul-2019
Version number5