ID   A375 NRAS (Q61K/+/+)
AC   CVCL_LC86
SY   NRAS (Q61K/+/+) A375
DR   cancercelllines; CVCL_LC86
DR   Horizon_Discovery; HD+118-001
DR   Wikidata; Q54606773
CC   Population: Caucasian.
CC   Characteristics: Heterozygous knockin of a NRAS activating mutation.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple_edited; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous; Note=By method not specified (Horizon_Discovery=HD+118-001).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0132 ! A-375
SX   Female
AG   54Y
CA   Cancer cell line
DT   Created: 22-08-17; Last updated: 30-01-24; Version: 14
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