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Cellosaurus NCI-H838 EGFR (L858R/+) (CVCL_LD05)

[Text version]

Cell line name NCI-H838 EGFR (L858R/+)
Synonyms EGFR (L858R/+) NCI-H838
Accession CVCL_LD05
Resource Identification Initiative To cite this cell line use: NCI-H838 EGFR (L858R/+) (RRID:CVCL_LD05)
Comments Characteristics: Heterozygous knockin of a EGFR activating mutation.
Sequence variations Mutation; HGNC; 11110; ARID1A; Simple; p.Pro1876Serfs*22 (c.5625_5632del) (p.CPP1657fs) (c.5621_5628delGCCCACCA); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 3236; EGFR; Simple_edited; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous; Note=By method not specified (Horizon Discovery).
Mutation; HGNC; 11998; TP53; Simple; p.Glu62Ter (c.184G>T); ClinVar=VCV000617472; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1594 (NCI-H838)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
Cell line collections Horizon_Discovery; HD+114-005
Other Wikidata; Q54908130
Entry history
Entry creation22-Aug-2017
Last entry update20-May-2021
Version number6