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Cellosaurus RKO EGFR (L858R/+) (CVCL_LD07)

[Text version]

Cell line name RKO EGFR (L858R/+)
Synonyms EGFR (L858R/+) RKO
Accession CVCL_LD07
Resource Identification Initiative To cite this cell line use: RKO EGFR (L858R/+) (RRID:CVCL_LD07)
Comments Characteristics: Heterozygous knockin of a EGFR activating mutation.
Sequence variations Heterozygous for EGFR p.Leu858Arg (c.2573T>G) (ClinVar=VCV000016609).
Heterozygous for ACVR2A p.Lys437fs*19 (c.1309_1310delAA) and p.Lys437fs*5 (c.1310delA) (from parent cell line).
Heterozygous for BRAF p.Val600Glu (c.1799T>A) (ClinVar=VCV000013961) (from parent cell line).
PIK3CA p.His1047Arg (c.3140A>G) (ClinVar=VCV000013652) (from parent cell line).
Heterozygous for TGFBR2 p.Lys128Serfs*35 (c.383delA) and p.Leu452Pro (c.1355T>C) (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0504 (RKO)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Web pages https://www.horizondiscovery.com/human-egfr-l858r-rko-cell-line-hd-106-006
Cross-references
Other Wikidata; Q54950545
Entry history
Entry creation22-Aug-2017
Last entry update02-Jul-2020
Version number5