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Cellosaurus MCF-10A PIK3CA (E545K/+) (CVCL_LD75)

[Text version]
Cell line name MCF-10A PIK3CA (E545K/+)
Synonyms PIK3CA (E545K/+) MCF10A
Accession CVCL_LD75
Resource Identification Initiative To cite this cell line use: MCF-10A PIK3CA (E545K/+) (RRID:CVCL_LD75)
Comments Characteristics: Heterozygous knockin of a PIK3CA helix domain activating mutation.
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008359.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple_edited; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous; Note=By method not specified (Horizon_Discovery=HD+101-002).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0598 (MCF-10A)
Sex of cell Female
Age at sampling 36Y
Category Spontaneously immortalized cell line
Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+101-002
Encyclopedic resources Wikidata; Q54904288
Entry history
Entry creation22-Aug-2017
Last entry update30-Jan-2024
Version number13