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Cellosaurus RKO EGFR (delE746-A750/+) (CVCL_LE01)

[Text version]

Cell line name RKO EGFR (delE746-A750/+)
Synonyms EGFR (delE746-A750/+) RKO
Accession CVCL_LE01
Resource Identification Initiative To cite this cell line use: RKO EGFR (delE746-A750/+) (RRID:CVCL_LE01)
Comments Characteristics: Heterozygous knockin of a EGFR activating mutation.
Sequence variations Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 3236; EGFR; Simple_edited; p.Glu746_Ala750del; Zygosity=Heterozygous; Note=By method not specified (Horizon Discovery).
Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0504 (RKO)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Cross-references
Cell line collections Horizon_Discovery; HD+106-009
Other Wikidata; Q54950544
Entry history
Entry creation22-Aug-2017
Last entry update20-May-2021
Version number8