Cellosaurus SKBR3-LR (CVCL_LG17)

Cell line name SKBR3-LR
Accession CVCL_LG17
Resource Identification Initiative To cite this cell line use: SKBR3-LR (RRID:CVCL_LG17)
Comments Selected for resistance to: ChEBI; CHEBI:49603; Lapatinib (Tykerb; Tyverb).
Sequence variation: Homozygous for TP53 p.Arg175His (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0033 (SK-BR-3)
Sex of cell Female
Age at sampling 43Y
Category Cancer cell line
Publications

PubMed=24876102; DOI=10.1158/0008-5472.CAN-13-2053
Rani S., Corcoran C., Shiels L., Germano S., Breslin S., Madden S., McDermott M.S., Browne B.C., O'Donovan N., Crown J., Gogarty M., Byrne A.T., O'Driscoll L.
Neuromedin U: a candidate biomarker and therapeutic target to predict and overcome resistance to HER-tyrosine kinase inhibitors.
Cancer Res. 74:3821-3833(2014)