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Cellosaurus SKBR3-TR (CVCL_LG19)

[Text version]

Cell line name SKBR3-TR
Accession CVCL_LG19
Resource Identification Initiative To cite this cell line use: SKBR3-TR (RRID:CVCL_LG19)
Comments Selected for resistance to: DrugBank; DB00072; Trastuzumab (Herceptin).
Sequence variations Homozygous for CDH1 deletion (from parent cell line).
Homozygous for TP53 p.Arg175His (c.524G>A) (ClinVar=VCV000012374) (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0033 (SK-BR-3)
Sex of cell Female
Age at sampling 43Y
Category Cancer cell line

PubMed=24876102; DOI=10.1158/0008-5472.CAN-13-2053
Rani S., Corcoran C., Shiels L., Germano S., Breslin S., Madden S.F., McDermott M.S., Browne B.C., O'Donovan N., Crown J., Gogarty M., Byrne A.T., O'Driscoll L.
Neuromedin U: a candidate biomarker and therapeutic target to predict and overcome resistance to HER-tyrosine kinase inhibitors.
Cancer Res. 74:3821-3833(2014)

Other Wikidata; Q54954677
Entry history
Entry creation15-Nov-2017
Last entry update02-Jul-2020
Version number5