Cellosaurus HCC1954-NR (CVCL_LG21)

Cell line name HCC1954-NR
Accession CVCL_LG21
Resource Identification Initiative To cite this cell line use: HCC1954-NR (RRID:CVCL_LG21)
Comments Selected for resistance to: ChEBI; CHEBI:61397; Neratinib (Nerlynx; HKI-272).
Sequence variations Heterozygous for PIK3CA p.His1047Arg (c.3140A>G) (from parent cell line).
Homozygous for TP53 p.Tyr163Cys (from parent cell line).
Disease Ductal breast carcinoma (NCIt: C4017)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1259 (HCC1954)
Sex of cell Female
Age at sampling 61Y
Category Cancer cell line
Publications

PubMed=24876102; DOI=10.1158/0008-5472.CAN-13-2053
Rani S., Corcoran C., Shiels L., Germano S., Breslin S., Madden S., McDermott M.S., Browne B.C., O'Donovan N., Crown J., Gogarty M., Byrne A.T., O'Driscoll L.
Neuromedin U: a candidate biomarker and therapeutic target to predict and overcome resistance to HER-tyrosine kinase inhibitors.
Cancer Res. 74:3821-3833(2014)