| Cell line name |
Jurkat 1F2-hGITR |
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| Synonyms |
1F2-hGITR |
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| Accession |
CVCL_LH48 |
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| Resource Identification Initiative |
To cite this cell line use: Jurkat 1F2-hGITR (RRID:CVCL_LH48) |
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| Comments |
Population: Caucasian.
Characteristics: One of the two IL2 alleles was inactived by CRISPR/Cas9 and a luciferase reporter gene was inserted in the loci thus expressing the luciferase gene under the control of endogenous IL2 promoter.
Knockout cell: Method=CRISPR/Cas9; HGNC; 6001; IL2 (Note=1 of 2 alleles).
Transfected with: HGNC; 11914; TNFRSF18.
Transfected with: UniProtKB; P08659; Firefly luciferase.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
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| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_LH47 (Jurkat 1F2) |
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| Sex of cell |
Male |
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| Age at sampling |
14Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=28847736; DOI=10.1016/j.jim.2017.08.006
Liu J.-Q., Liu R., Gray P., Liu Z.-Y., Cui X.-X., Li G.-H., Liu Z.
Development of a luciferase reporter Jurkat cell line under the control of endogenous interleukin-2 promoter.
J. Immunol. Methods 451:48-53(2017) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_LH48
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| Encyclopedic resources |
Wikidata; Q54899128
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| Entry history |
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| Entry creation | 15-Nov-2017 |
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| Last entry update | 30-Jan-2024 |
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| Version number | 16 |
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