Cellosaurus cell line HATL (CVCL_LI16)

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Cell line name	HATL
Accession	CVCL_LI16
Resource Identification Initiative	To cite this cell line use: HATL (RRID:CVCL_LI16)
Comments	Population: Caucasian. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084.
Sequence variations	Mutation; HGNC; 11998; TP53; Simple; p.Arg175Pro (c.524G>C); Zygosity=Heterozygous (PubMed=8486778).
Disease	Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_LI15 ! HABL
Sex of cell	Female
Age at sampling	10Y
Category	Cancer cell line
Publications	PubMed=8486778; DOI=10.1172/JCI116435 Yeargin J., Cheng J., Yu A.L.-T., Gjerset R.A., Bogart M., Haas M. P53 mutation in acute T cell lymphoblastic leukemia is of somatic origin and is stable during establishment of T cell acute lymphoblastic leukemia cell lines. J. Clin. Invest. 91:2111-2117(1993) PubMed=10637496; DOI=10.1038/sj.leu.2401604 Drexler H.G., Fombonne S., Matsuo Y., Hu Z.-B., Hamaguchi H., Uphoff C.C. p53 alterations in human leukemia-lymphoma cell lines: in vitro artifact or prerequisite for cell immortalization? Leukemia 14:198-206(2000)
Encyclopedic resources	Wikidata; Q54881331
Entry history
Entry creation	15-Nov-2017
Last entry update	29-Jun-2023
Version number	8