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Cellosaurus CWR22Pc (CVCL_LI38)

[Text version]
Cell line name CWR22Pc
Accession CVCL_LI38
Resource Identification Initiative To cite this cell line use: CWR22Pc (RRID:CVCL_LI38)
Comments Population: Caucasian.
Characteristics: Androgen-dependent. Expresses full-length AR and PSA.
Derived from site: In situ; Prostate; UBERON=UBERON_0002367.
Sequence variations
  • Mutation; HGNC; 644; AR; Simple; p.His875Tyr (c.2623C>T); ClinVar=VCV000009834; Zygosity=Hemizygous (PubMed=18829484).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3967 (CWR22)
Sex of cell Male
Age at sampling Adult
Category Cancer cell line
STR profile Source(s): PubMed=27271795

Markers:
AmelogeninX,Y
CSF1PO10,11
D3S135813,14,15
D5S81811,12
D7S8209,10,11
D8S117913
D13S3178,12
D16S53912
D18S5114
D21S1130
FGA20,23
Penta D9,12
Penta E5,13
TH016,9.3
TPOX8
vWA15,18

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Publications

PubMed=18829484; DOI=10.1158/1078-0432.CCR-08-0979
Dagvadorj A., Tan S.-H., Liao Z.-Y., Cavalli L.R., Haddad B.R., Nevalainen M.T.
Androgen-regulated and highly tumorigenic human prostate cancer cell line established from a transplantable primary CWR22 tumor.
Clin. Cancer Res. 14:6062-6072(2008)

PubMed=21248069; DOI=10.1158/0008-5472.CAN-10-1998
Li Y.-M., Alsagabi M., Fan D.-H., Bova G.S., Tewfik A.H., Dehm S.M.
Intragenic rearrangement and altered RNA splicing of the androgen receptor in a cell-based model of prostate cancer progression.
Cancer Res. 71:2108-2117(2011)

PubMed=27271795; DOI=10.1002/pros.23190
Shourideh M., DePriest A., Mohler J.L., Wilson E.M., Koochekpour S.
Characterization of fibroblast-free CWR-R1ca castration-recurrent prostate cancer cell line.
Prostate 76:1067-1077(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_LI38
Encyclopedic resources Wikidata; Q54817055
Entry history
Entry creation15-Nov-2017
Last entry update05-Oct-2023
Version number10