Cellosaurus logo
expasy logo

Cellosaurus HT-29/B6 (CVCL_LJ30)

[Text version]
Cell line name HT-29/B6
Synonyms HT29/B6
Accession CVCL_LJ30
Resource Identification Initiative To cite this cell line use: HT-29/B6 (RRID:CVCL_LJ30)
Comments Population: Caucasian.
Characteristics: Derived from a glucose-free culture of HT-29.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0320 (HT-29)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
Publications

PubMed=1656765; DOI=10.1152/ajpcell.1991.261.4.C574
Kreusel K.-M., Fromm M., Schulzke J.-D., Hegel U.
Cl- secretion in epithelial monolayers of mucus-forming human colon cells (HT-29/B6).
Am. J. Physiol. 261:C574-C582(1991)

PubMed=11533143; DOI=10.1111/j.1469-7793.2001.00541.x
Bojarski C., Gitter A.H., Bendfeldt K., Mankertz J., Schmitz H., Wagner S., Fromm M., Schulzke J.-D.
Permeability of human HT-29/B6 colonic epithelium as a function of apoptosis.
J. Physiol. (Lond.) 535:541-552(2001)

Cross-references
Cell line databases/resources cancercelllines; CVCL_LJ30
Encyclopedic resources Wikidata; Q54896526
Entry history
Entry creation15-Nov-2017
Last entry update05-Oct-2023
Version number15